General Information
-
DRAMP ID
- DRAMP29253
-
Peptide Name
- Peptide 3
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GGVLVQPG
-
Sequence Length
- 8
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial,Antiviral(SARS-CoV-2)
-
Target Organism
-
- [Ref.34502335]Virus:SARS-CoV-2 UC-1074:inhibition of virus activity in Vero cells(EC50>20 μM);
- SARS-CoV-2 UC-1075:inhibition of virus activity in Vero cells(EC50>20 μM);
- cytomegalovirus (HCMV) AD-169 Strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>20 µM);
- cytomegalovirus (HCMV) Davis strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>100 µM);
- varicella-zoster virus (VZV) TK+ VZV Strain OKA:inhibition of virus activity in human embryonic lung (HEL) cells(EC50=58.09 µM);
- varicella-zoster virus (VZV) TK-VZV Strain 07–1:inhibition of virus activity in human embryonic lung (HEL) cells(EC50=81.09 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- [Ref.34502335]Vero cell:CC50=81.8 ± 2.1 µM.
-
Binding Target
- Main protease
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Acylation
-
C-terminal Modification
- Methyl amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29253.
Physicochemical Information
-
Formula
- C32H55N9O10
Absent Amino Acids
- ACDEFHIKMNRSTWY
Common Amino Acids
- G
Mass
- 725.84
PI
- 5.52
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- 0
-
Boman Index
- 1028
Hydrophobicity
- 0.738
Aliphatic Index
- 121.25
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP29253
Comments Information
Function
- Antiviral activity against Influenza virus.
Literature Information
- ·Literature 1
-
Title
- Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation.
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Pubmed ID
- 34502335
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Reference
- Int J Mol Sci. 2021 Aug 30;22(17):9427.
-
Author
- Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A.