General Information

    • DRAMP ID

    • DRAMP29254

    • Peptide Name

    • Peptide 4

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GGVLVQPG

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial,Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.34502335]Virus:SARS-CoV-2 UC-1074:inhibition of virus activity in Vero cells(EC50≥20 μM);
      • SARS-CoV-2 UC-1075:inhibition of virus activity in Vero cells(EC50>20 μM);
      • cytomegalovirus (HCMV) AD-169 Strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>20 µM);
      • cytomegalovirus (HCMV) Davis strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50=100 µM);
      • varicella-zoster virus (VZV) TK+ VZV Strain OKA:inhibition of virus activity in human embryonic lung (HEL) cells(EC50=78.20 µM);
      • varicella-zoster virus (VZV) TK-VZV Strain 07–1:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>100 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.34502335]Vero cell:CC50=74.9 ± 4.9 µM.

    • Binding Target

    • Main protease

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Pivaloylation

    • C-terminal Modification

    • Methyl amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29254 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29254.

Physicochemical Information

    • Formula

    • C32H55N9O10

    • Absent Amino Acids

    • ACDEFHIKMNRSTWY

    • Common Amino Acids

    • G

    • Mass

    • 725.84

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • 0

    • Boman Index

    • 1028

    • Hydrophobicity

    • 0.738

    • Aliphatic Index

    • 121.25

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP29254

Comments Information

    • Function

    • Antiviral activity against Influenza virus.

Literature Information

  • ·Literature 1

    • Title

    • Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation.

    • Reference

    • Int J Mol Sci. 2021 Aug 30;22(17):9427.

    • Author

    • Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A.