• DRAMP ID

    • DRAMP29255
    • Peptide Name

    • Peptide 5
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GVLVQ
    • Sequence Length

    • 5
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial,Antiviral(SARS-CoV-2)
    • Target Organism

      • [Ref.34502335]Virus:SARS-CoV-2 UC-1074:inhibition of virus activity in Vero cells(EC50≥20 μM);
      • SARS-CoV-2 UC-1075:inhibition of virus activity in Vero cells(EC50>20 μM);
      • cytomegalovirus (HCMV) AD-169 Strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>20 µM);
      • cytomegalovirus (HCMV) Davis strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>100 µM);
      • varicella-zoster virus (VZV) TK+ VZV Strain OKA:inhibition of virus activity in human embryonic lung (HEL) cells(EC50=59.80 µM);
      • varicella-zoster virus (VZV) TK-VZV Strain 07–1:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>100 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • [Ref.34502335]Vero cell:CC50=75.0 ±2.2 µM.
    • Binding Target

    • Main protease
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Acylation
    • C-terminal Modification

    • Methyl amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP29255 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29255.
    • Formula

    • C23H42N6O7
    • Absent Amino Acids

    • ACDEFHIKMNPRSTWY
    • Common Amino Acids

    • V
    • Mass

    • 514.62
    • PI

    • 5.52
    • Basic Residues

    • 0
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 3
    • Net Charge

    • 0
    • Boman Index

    • 840
    • Hydrophobicity

    • 1.66
    • Aliphatic Index

    • 194
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 1

DRAMP29255

    • Function

    • Antiviral activity against Influenza virus.
  • ·Literature 1
    • Title

    • Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation.
    • Reference

    • Int J Mol Sci. 2021 Aug 30;22(17):9427.
    • Author

    • Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A.