General Information

    • DRAMP ID

    • DRAMP29258

    • Peptide Name

    • compound 2

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • YXKXKXXKXXKC

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial,Antiviral

    • Target Organism

      • [Ref.30783498]Virus:Zika Virus(ZIKV):inhibition of flaviviral Protease(Zika virus NS2B-NS3 protease) activity in Huh-7 cells(IC50=0.25 ± 0.01 μM);
      • Dengue virus serotype 2:inhibition of flaviviral Protease(Zika virus NS2B-NS3 protease) activity in Huh-7 cells(IC50=1.7 ± 0.1 μM);
      • West Nile virus:inhibition of flaviviral Protease(West Nile virus NS2B-NS3 protease) activity in Huh-7 cells(IC50=3.9 ± 0.4 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • NS2B-NS3 protease

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Thioether-acyl moiety (−S-Ac−)(forms a macrocycle through the side chain of the underlined cysteine residue)

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • The 'X' at position 2,7,9 and 10 indicates MeYMe(N-methyl-4-O-methyl-tyrosine), position 4 indicates MeF(N-methyl-phenylalanine), position 6 indicates MeS(N-methyl-serine).

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29258 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29258.

Physicochemical Information

    • Formula

    • C36H52N10O2S

    • Absent Amino Acids

    • ADEFGHILMNPQRSTVW

    • Common Amino Acids

    • X

    • Mass

    • 1465.01

    • PI

    • 9.87

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 0

    • Net Charge

    • +4

    • Boman Index

    • -2106

    • Hydrophobicity

    • -1.2

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 2

DRAMP29258

Comments Information

    • Function

    • Antiviral activity against Influenza virus.

Literature Information

  • ·Literature 1

    • Title

    • De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease.

    • Reference

    • ACS Med Chem Lett. 2019 Jan 4;10(2):168-174.

    • Author

    • Nitsche C, Passioura T, Varava P, Mahawaththa MC, Leuthold MM, Klein CD, Suga H, Otting G.