General Information
-
DRAMP ID
- DRAMP29264
-
Peptide Name
- E1P37-1
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- VPNLTCAVACELKWESEF
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial,Antiviral
-
Target Organism
-
- [Ref.26905802]Virus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells(IC50=80.0 ± 62.4 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- gp41
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29264.
Physicochemical Information
-
Formula
- C91H139N21O28S2
Absent Amino Acids
- DGHIMQRY
Common Amino Acids
- E
Mass
- 2039.35
PI
- 4.25
Basic Residues
- 1
Acidic Residues
- 3
Hydrophobic Residues
- 8
Net Charge
- -2
-
Boman Index
- -918
Hydrophobicity
- 0.306
Aliphatic Index
- 86.67
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5625
Absorbance 280nm
- 330.88
Polar Residues
- 5
DRAMP29264
Comments Information
Function
- Antiviral activity against Influenza virus.
Literature Information
- ·Literature 1
-
Title
- Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor.
-
Pubmed ID
- 26905802
-
Reference
- Biochim Biophys Acta. 2016 Jun;1860(6):1139-48.
-
Author
- Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I.