General Information
-
DRAMP ID
- DRAMP29282
-
Peptide Name
- E1P43-1
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- WRWTEQLASNYWILEYLW
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial,Antiviral
-
Target Organism
-
- [Ref.26905802]Virus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells(IC50=6.8 ± 0.3 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- gp41
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29282.
Physicochemical Information
-
Formula
- C121H161N27O29
Absent Amino Acids
- CDFGHKMPV
Common Amino Acids
- W
Mass
- 2457.77
PI
- 4.53
Basic Residues
- 1
Acidic Residues
- 2
Hydrophobic Residues
- 9
Net Charge
- -1
-
Boman Index
- -1616
Hydrophobicity
- -0.472
Aliphatic Index
- 92.22
Half Life
-
- Mammalian:2.8 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 24980
Absorbance 280nm
- 1469.41
Polar Residues
- 5
DRAMP29282
Comments Information
Function
- Antiviral activity against Influenza virus.
Literature Information
- ·Literature 1
-
Title
- Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor.
-
Pubmed ID
- 26905802
-
Reference
- Biochim Biophys Acta. 2016 Jun;1860(6):1139-48.
-
Author
- Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I.