General Information
-
DRAMP ID
- DRAMP29293
-
Peptide Name
- E1P47
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- WILEYLWKVPFDFWRGVI
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial,Antiviral
-
Target Organism
-
- [Ref.26905802]Virus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells(IC50=2.7 ± 0.3 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- gp41
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29293.
Physicochemical Information
-
Formula
- C122H167N25O24
Absent Amino Acids
- ACHMNQST
Common Amino Acids
- W
Mass
- 2367.82
PI
- 6.07
Basic Residues
- 2
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- 0
-
Boman Index
- 551
Hydrophobicity
- 0.511
Aliphatic Index
- 118.89
Half Life
-
- Mammalian:2.8 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 17990
Absorbance 280nm
- 1058.24
Polar Residues
- 2
DRAMP29293
Comments Information
Function
- Antiviral activity against Influenza virus.
Literature Information
- ·Literature 1
-
Title
- Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor.
-
Pubmed ID
- 26905802
-
Reference
- Biochim Biophys Acta. 2016 Jun;1860(6):1139-48.
-
Author
- Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I.