Result: 81 - 96 of 96
DRAMP IDNAMEDescriptionMedical_useStage of developmentCompany
DRAMP29318PXL01Synthetic macrocyclic 25-amino acid peptide derived from human lactoferricinPrevention of post-surgical adhesion formation in hand surgeryPhase II/IIIPromore Pharma (formerly Pergamum AB)
DRAMP29319HXP124Plant defensinFungal nail infection (onychomycosis)Phase IIHexima
DRAMP29320DPK-060Derived from kininogen, cationic random-coil peptideAtopic dermatitis, Otitis externaPhase IIDermaGen AB/Pergamum AB/Karolinska Development AB
DRAMP29321Lotilibcin(WAP-8294A2)LipodepsipeptideMethicillin-resistant S. aureusPhase I/IIaRigen Pharmaceuticals, Green Cross Corporation
DRAMP29322NVB302Synthetic type B lantibioticC. difficile infectionsPhase INovacta Biosystems Ltd.
DRAMP29323EA360Linear tetrapeptide, derived from human chorionic gonadotropinSystemic inflammatory response and renal functionPhase IIa/b currentExponential Biotherapies
DRAMP29324Friulimicin BFriulimicin B is a naturally occurring antibiotic produced by a micro-organism, *Actinoplanes friuliensis*. It shows strong cidal activity against a number of Gram-positive pathogens which commonly cause serious infections in hospital patients and which are becoming more routinely acquired in the community.Pneumonia, staphylococcal skin infectionsPhase IMerLion/Pharmaceuticals
DRAMP29325TD-1792(Cefilavancin)Cefilavancin is a covalently-linked glycopeptide-cephalosporin (beta-lactam) heterodimer antibiotic that exhibits substantially greater activity than its component parts against Gram-positive bacteria.Gram-positive infections, Skin and soft tissue infectionsPhase IIIGlaxoSmithKline Co., Theravance Biopharma Inc., R-Pharm
DRAMP29326LTX-315(Oncopore, Ruxotemitide)Ruxotemitide is a peptide derived from human lactoferrin, with potential lytic and immunostimulating activities. Solid tumorsPhase ILytix Biopharma
DRAMP29327ANG1005(Paclitaxel trevatide)Paclitaxel Trevatide is a peptide-drug conjugate containing the taxane paclitaxel covalently linked to the proprietary 19 amino acid peptide angiopep-2, in a 3:1 ratio, with potential antineoplastic activity. Breast cancer, brain metastasesPhase IIAngiochem Inc.
DRAMP29328Polymyxin BPolymyxin B is a polymyxin antibiotic used to treat a wide variety of infections in the body.They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes.Treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosaIn marketUnknown
DRAMP29329TyrothricinA polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.Tyrothricin is a topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.Treatment of infected skin and infected oropharyngeal mucous membranesIn marketUnknown
DRAMP29330VancomycinVancomycin is a glycopeptide antibiotic used to treat severe but susceptible bacterial infections such as MRSA (methicillin-resistant Staphylococcus aureus) infections.Treatment of septicemia, infective endocarditis, skin and skin structure infections, bone infections, and lower respiratory tract infections.In marketUnknown
DRAMP29331Onc72derived from OncocinTreatment of antibiotic-susceptible K. pneumoniaePreclinicalUnknown
DRAMP29332Gramicidin SCyclic peptide biosynthesized from gramicidin in Bacillus brevis; comprises two identical pentapeptides coupled head to tail.Potent against gram-negative and gram-positive bacteria and fungi restricted use as spermicide and to treat genital ulcers caused by STDIn marketUnknown
DRAMP29333Gramicidin DGramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. Active against most Gram-positive bacteria and some Gram-negative organisms, Gramicidin D is used primarily as a topical antibiotic and is also found in Polysporin ophthalmic solution.Skin lesions, surface wounds and eye infectionsIn marketUnknown
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