General Information

    • DRAMP ID

    • DRAMP37198

    • Peptide Name

    • BR2GK(Brevinin-2GHk)

    • Source

    • Fejervarya multistriata

    • Family

    • Belongs to the Brevinin-2 subfamily

    • Gene

    • Not found

    • Sequence

    • FSSLFKAGAKYLLKQVGKAGAQQLACKAANNC

    • Sequence Length

    • 32

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 29213(MIC=10μmol/L), Staphylococcus aureus ATCC 25923(MIC=20μmol/L), Enterococcus faecalis ATCC 29212(MIC=20μmol/L)
      • Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=40μmol/L, Escherichia coli ATCC 35218(MIC>80μmol/L), Pseudomonas aeruginosa ATCC 27853(MIC>80μmol/L), Klebsiella pneumoniae ATCC 27853(MIC>80μmol/L),acinetobacter baumannii ATCC 19606(MIC=40μmol/L)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • BR2GK exhibits a random helical conformation in water.BR2GK dissolved in an SDS solution that simulates a cell membrane environment has an α-helical structure.

    • Predicted Structure

    • There is no predicted structure for DRAMP37198.

Literature Information

  • ·Literature 1

    • Title

    • 蛙皮肤来源抗菌肽Brevinin-2GHk的抗菌作用机制; Antibacterial mechanism of Brevinin-2GHk, an antimicrobial peptide from Fejervarya limnocharis skin

    • doi

    • 10.12122/j.issn.1673-4254.2021.11.09

    • Reference

    • [J].南方医科大学学报,2021,41(11):1657-1663.

    • Author

    • 熊唯琛,柴金为,吴洁娜,田茂林,卢万成,徐学清:XIONG Weichen,CHAI Jinwei,WU Jiena,TIAN Maolin,LU Wancheng,XU Xueqing