General Information

    • DRAMP ID

    • DRAMP37200

    • Peptide Name

    • LEAP-2（contains signal peptide and precursor peptide）

    • Source

    • Homo sapiens

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • MWHLKLCAVLMIFLLLLGQIDGSPIPEVSSAKRRPRRMTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE

    • Sequence Length

    • 77

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus megaterium

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix、Random coil

    • Structure Description

    • Alpha helix accounted for 54.55%, and 42 amino acid residues participated. The β-angle accounted for 2.6% and was involved by 2 amino acid residues. Random coil accounted for 42.9%, and 33 amino acid residues were involved

    • Predicted Structure

    • There is no predicted structure for DRAMP37200.

Literature Information

  • ·Literature 1

    • Title

    • 人Ⅱ型肝脏表达抗菌肽LEAP-2的生物信息学分析; Bioinformatics Analysis of Human Liver-expressed Antimicrobial Peptide 2

    • doi

    • 10.13417/j.gab.041.000407.

    • Reference

    • [J].基因组学与应用生物学,2022,41(02):407-414.DOI:10.13417/j.gab.041.000407.

    • Author

    • 王珊珊,高琪,任艳艳,路宏朝,王令,张涛:Wang Shanshan,Gao Qi,Ren Yanyan,Lu Hongzhao,Wang Ling,Zhang Tao