General Information

    • DRAMP ID

    • DRAMP37216

    • Peptide Name

    • C4(Peptide derived from Cn-AMP1)

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • MGQARGAVSSVAGRAQGM

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus CICC 23656 (MIC=16 µM), Staphylococcus epidermidis CICC 10294 (MIC=64 µM), Clostridium perfringens ATCC 13124 (MIC=16 µM), Bacillus cereus CICC 23828 (MIC=32 µM), Streptococcus pyogenes CICC 10373 (MIC=32 µM), Streptococcus faecalis CICC 23658 (MIC=16 µM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=32 µM),Pseudomonas aeruginosa CICC 21636 (MIC=64 µM),Salmonella Enteritidis CICC 21535 (MIC=64 µM),Klebsiella pneumonia ATCC 10031 (MIC=32 µM), Shigella baumannii ATCC 9027(MIC=16 µM), Enterobacter sakazakii CICC 21544(MIC=16 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • IC50 = 445.2 μM targeting on BEAS-2B cell cultured in DMEM-H medium containing 11% fetal bovine serum. The original article did not specify a positive control.

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Predicted Structure

    • There is no predicted structure for DRAMP37216.

Literature Information

  • ·Literature 1

    • Title

    • 基于短链抗菌肽Cn-AMP1的拼接肽合成及抗菌活性研究; Study on synthesis and antibacterial activity of splicing peptides based on short chain antibacterial peptide Cn-AMP1

    • doi

    • 10.13819/j.issn.2096-708X.2021.05.001

    • Reference

    • [J].齐齐哈尔医学院学报,2023,44(23):2208-2211.

    • Author

    • 陈柯,衣同辉,王宏兰,房丹丹,刘大鹏,高涵,潘洪明,李淑艳,王洁,刘桃源:Chen Ke,Yi Tonghui,Wang Honglan,Fang Dandan,Liu Dapeng,Gao Han,Pan Hongming,Li Shuyan,Wang Jie,Liu Taoyuan