General Information

    • DRAMP ID

    • DRAMP37226

    • Peptide Name

    • La39

    • Source

    • Liocheles australasiae

    • Family

    • Belongs to the NDBPs family(NDBP:non-disulfide-bridged peptide)

    • Gene

    • Not found

    • Sequence

    • FPFLLSLIPSAISALKKL

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=50μg/mL)
      • Gram-negative bacteria: Escherichia coli (MIC＞200μg/mL)

    • Hemolytic Activity

      • HD50 = 99.6μg/mL against on human red blood cells . 1% Triton X-100 were used as the positive control.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • La39 is α-helical polypeptide with high surface polarity and overall hydrophobicity

    • Predicted Structure

    • There is no predicted structure for DRAMP37226.

Literature Information

  • ·Literature 1

    • Title

    • 蝎毒素抗菌肽La39的序列分析及功能鉴定; Functional identification and bioinformation analysis of antimicrobial peptide from scorpion venom

    • doi

    • 10.3969/j.issn.2095-736.2022.01.033

    • Reference

    • [J].生物学杂志,2022,39(01):33-36.

    • Author

    • 朱晨刚,贾庭:ZHU Chengang,JIA Ting