General Information

    • DRAMP ID

    • DRAMP37227

    • Peptide Name

    • ET12

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKKVIVIRRWFI

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=64μg/mL), Staphylococcus epidermidis ATCC 12228 (MIC=8μg/mL), Staphylococcus epidermidis ATCC 35984 (MIC=16μg/mL)
      • Gram-negative bacteria: Acinetobacter baumannii aba 658 (MIC=256μg/mL), Acinetobacter baumannii aba 659 (MIC=32μg/mL), Acinetobacter baumannii aba 660 (MIC=64μg/mL), Acinetobacter baumannii aba 661 (MIC=128μg/mL), Acinetobacter baumannii aba 662 (MIC=128μg/mL), Pseudomonas aeruginosa ATCC 25922 (MIC＞256μg/mL), Escherichia coli ATCC 25922 (MIC＞256μg/mL)， Klebsiella pneumoniae 1206 (MIC＞256μg/mL).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Predicted Structure

    • There is no predicted structure for DRAMP37227.

Literature Information

  • ·Literature 1

    • Title

    • 抗菌肽ET12对革兰阳性菌的抗菌活性及机制研究; Antibacterial activity and mechanism of antimicrobial peptide ET12 against Gram-positive bacteria

    • doi

    • 10.16016/j.1000-5404.202003346

    • Reference

    • [J].第三军医大学学报,2020,42(15):1567-1572.DOI:10.16016/j.1000-5404.202003346.

    • Author

    • 袁慊,冯伟,王瑜,姚璞: YUAN Qian,FENG Wei,WANG Yu,YAO Pu,SUN Fengjun