• DRAMP ID

    • DRAMP37248
    • Peptide Name

    • SAMP1-A4(Derived from SAMP1)
    • Source

    • Sythetic
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • VRLLRRRI
    • Sequence Length

    • 8
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=3.9μg/mL), Bacillus subtilis (MIC=0.95μg/mL), Listeria monocytogenes (MIC=0.95μg/mL)
      • Gram-negative bacteria: Candida tropicalis (MIC=3.9μg/mL), Escherichia coli (MIC=3.9μg/mL), Pseudomonas aeruginosa 27853(MIC=7.8μg/mL).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Cell membrane
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Alpha helix
    • Structure Description

    • The secondary structure of SAMP1 and most similar peptides is dominated by α helix and random curling. In 54% (volume fraction) TFE solution, the proportion of alpha helix increases.
    • Predicted Structure

    • There is no predicted structure for DRAMP37248.
  • ·Literature 1
    • Title

    • 抗菌肽SAMP1及其类似肽的构效关系; Structure-activity Relationship of Antimicrobial Peptide SAMP1 and Its Analog Peptides
    • doi

    • 10.7503/cjcu20180680
    • Reference

    • [J].高等学校化学学报,2019,40(04):705-711.
    • Author

    • 常俊朋,赵佳瑞,陈思佳,孟凯,石微妮,李瑞芳:CHANG Junpeng,ZHAO Jiarui,CHEN Sijia,MENG Kai,SHI Weini,LI Ruifang