General Information

    • DRAMP ID

    • DRAMP37248

    • Peptide Name

    • SAMP1-A4(Derived from SAMP1)

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VRLLRRRI

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=3.9μg/mL), Bacillus subtilis (MIC=0.95μg/mL), Listeria monocytogenes (MIC=0.95μg/mL)
      • Gram-negative bacteria: Candida tropicalis (MIC=3.9μg/mL), Escherichia coli (MIC=3.9μg/mL), Pseudomonas aeruginosa 27853(MIC=7.8μg/mL).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • The secondary structure of SAMP1 and most similar peptides is dominated by α helix and random curling. In 54% (volume fraction) TFE solution, the proportion of alpha helix increases.

    • Predicted Structure

    • There is no predicted structure for DRAMP37248.

Literature Information

  • ·Literature 1

    • Title

    • 抗菌肽SAMP1及其类似肽的构效关系; Structure-activity Relationship of Antimicrobial Peptide SAMP1 and Its Analog Peptides

    • doi

    • 10.7503/cjcu20180680

    • Reference

    • [J].高等学校化学学报,2019,40(04):705-711.

    • Author

    • 常俊朋,赵佳瑞,陈思佳,孟凯,石微妮,李瑞芳:CHANG Junpeng,ZHAO Jiarui,CHEN Sijia,MENG Kai,SHI Weini,LI Ruifang