General Information

    • DRAMP ID

    • DRAMP37249

    • Peptide Name

    • Hc-15(Derived from Hc-CATH)

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKRLLKSVRRAVKKF

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (CI) (MIC=4.69μg/mL), Nocardia asteroides(CI) (MIC=18.8μg/mL)
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=37.5μg/mL), Escherichia coli 1 (CIb) (MIC=18.8μg/mL), Escherichia coli 3 (CI) (MIC=37.5μg/mL), Shigella dysenteriae(CI) (MIC=4.69μg/mL), Proteus mirabilis (CI) (MIC=9.38μg/mL), Pseudomonas aeruginosa (CI) (MIC=37.5μg/mL), Pseudomonas aeruginosa 1 (CI) (MIC=4.69μg/mL), Salmonella paratyphi A (CI) (MIC=37.5μg/mL);
      • Fungus: Candida albicans(CI) (MIC=150μg/mL), Candida glabrata 1 (CI) (MIC=75μg/mL), Candida glabrata 2 (CI) (MIC=37.5μg/mL), Arcyria cinerea (CI) (MIC=18.9μg/mL)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Amphipathic alpha helix structure

    • Structure Description

    • Not found

    • Predicted Structure

    • There is no predicted structure for DRAMP37249.

Literature Information

  • ·Literature 1

    • Title

    • 青环海蛇抗菌肽Hc-CATH的分子设计及药效毒理优化; Molecular design, pharmacology and toxicology optimization of antimicrobial peptide from Hydrophis cyanocinctus, Hc-CATH

    • doi

    • 10.13345/j.cjb.200583

    • Reference

    • [J].生物工程学报,2021,37(07):2534-2542.DOI:10.13345/j.cjb.200583.

    • Author

    • 高久香,王义鹏,于海宁: Jiuxiang Gao,Yipeng Wang,Haining Yu