General Information

    • DRAMP ID

    • DRAMP37255

    • Peptide Name

    • LK

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLLKLGKLLLKGLKK

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923(MIC=2μmol/L), Staphylococcus aureus ATCC 29213(MIC=2μmol/L), Staphylococcus epidermidis ATCC 12228(MIC=2μmol/L), Bacillus subtilis CMCC 63501(MIC=2μmol/L)
      • Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=2μmol/L), Escherichia coli ATCC O78(MIC=4μmol/L), Salmonella pullorum C79-13(MIC=4μmol/L), Pseudomonas aeruginosa ATCC 27853(MIC=4μmol/L).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Exhibits obvious α-helical structure in trifluoroethanol buffer

    • Predicted Structure

    • There is no predicted structure for DRAMP37255.

Literature Information

  • ·Literature 1

    • Title

    • 利用亮氨酸和赖氨酸设计新型α-螺旋抗菌肽; Rational design of α-helical antimicrobial peptide with Leu and Lys residues

    • doi

    • 10.13344/j.microbiol.china.130153

    • Reference

    • [J].微生物学通报,2014,41(02):312-318.DOI:10.13344/j.microbiol.china.130153.

    • Author

    • 王良,马清泉,单安山,董娜,吕银凤:WANG Liang,MA Qing-Quan,SHAN An-Shan,DONG Na,Lü Yin-Feng