General Information

    • DRAMP ID

    • DRAMP37275

    • Peptide Name

    • dybowskin-1ST

    • Source

    • Rana dybowskii

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • MFTLKKSLLLLFFLGTISLSLCEEERNAEEERRDYPEERDVEVEKRIIPLPLGYFAKKT

    • Sequence Length

    • 59

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=0.75 µg/ml);
      • Gram-negative bacteria: Escherichia coli ATCC 43889(MIC=0.375 µg/ml), Pseudomonas aeruginosa CMCC 10104(MIC＞1.5 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • 26 amino acids participated in the formation of α-helix, accounting for 44.07%. 10 amino acids participated in the formation of the extended chain, accounting for 16.95%. Two amino acids participated in the formation of β-angle, accounting for 3.39%; 21 amino acids were involved in the formation of random curl, accounting for 35.39%.The secondary structure prediction showed that the protein was mainly α-helical.

    • Predicted Structure

    • There is no predicted structure for DRAMP37275.

Literature Information

  • ·Literature 1

    • Title

    • 东北林蛙抗菌肽dybowskin-1ST的结构预测及生物学活性分析; Structure prediction and biological activity analysis of dybowskin-1ST antimicrobial peptide in Rana dybowskii

    • doi

    • 10.13345/j.cjb.200564.

    • Reference

    • [J].生物工程学报,2021,37(08):2890-2902.DOI:10.13345/j.cjb.200564.

    • Author

    • 刘悦,邵学超,王天添,王鑫莹,李南,赵云冬,夏薇,孙丽媛:Yue Liu,Xuechao Shao,Tiantian Wang,Xinying Wang,Nan Li,Yundong Zhao,Wei Xia,Liyuan Sun