General Information

    • DRAMP ID

    • DRAMP37282

    • Peptide Name

    • CaDef2.1G27-K44

    • Source

    • Capsicum annuum

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLTRLRRILFRLLLWRTK

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Mycobacterium tuberculosis H37Rv (MIC50= 33.2 µM), Mycobacterium tuberculosis M299 (MIC50= 55.4 µM);
      • Fungus: Candida tropicalis(CE017) (MIC100= 50 µM), Candia Parapsilosis(CE002) (MIC100= 50 µM), Candida albicans(CE022) (MIC100= 25 µM), Candida buinensis(3982) (MIC100= 25 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • CC50 >200 μM targeting on macrophages and monocytes. 1%(v/v) Triton X-100 detergent at 37 ℃ for 1 h was used as the positive control.

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Enriched with turns and disordered conformations(59–61%) in aqueous solution and the presence of POPC.

    • Predicted Structure

    • There is no predicted structure for DRAMP37282.

Literature Information

  • ·Literature 1

    • Title

    • A new bioinspired peptide on defensin from C. annuum fruits: Antimicrobial activity, mechanisms of action and therapeutical potential

    • doi

    • 10.1016/J.BBAGEN.2022.130218

    • Reference

    • Biochimica et Biophysica Acta (BBA) - ISSN 0304-4165.

    • Author

    • Gabriel Bonan Taveira, Érica de Oliveira Mello, Thatiana Lopes Biá Ventura Simão, Milena Bellei Cherene, André de Oliveira Carvalho, Michelle Frazão Muzitano, Elena Lassounskaia, Saulo Pireda, Emílio de Castro Miguel, Luis Guilherme Mansor Basso, Maura Da Cunha, Olney Vieira da Motta, Valdirene Moreira Gomes.