General Information

    • DRAMP ID

    • DRAMP37363

    • Peptide Name

    • LP-M2(Derived from Lausporin-1)

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLRALWRVAKRLF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 29213(MIC=5μmol/L), Staphylococcus aureus ATCC 25923(MIC=5μmol/L), Enterococcus faecalis ATCC 29212(MIC=10μmol/L)
      • Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=5μmol/L, Escherichia coli ATCC 35218(MIC=10μmol/L), Pseudomonas aeruginosa ATCC 27853(MIC=10μmol/L), Klebsiella pneumoniae ATCC 27853(MIC=5μmol/L),acinetobacter baumannii ATCC 19606(MIC=5μmol/L)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Cationic α-helical antimicrobial peptide composed of 15 amino acid residues

    • Predicted Structure

    • There is no predicted structure for DRAMP37363.

Literature Information

  • ·Literature 1

    • Title

    • 基于蝎抗菌肽Lausporin-1设计衍生肽以优化其抗“ESKAPE”病原菌活性：Analogues Designed from Scorpion-Derived Peptide Lausporin-1 Exhibit Improved Antimicrobial Activity Against ‘ESKAPE’ Pathogens

    • doi

    • :10.13819/j.issn.2096-708X.2021.05.001.

    • Reference

    • [J].湖北医药学院学报,2021,40(05):441-445+453.DOI:10.13819/j.issn.2096-708X.2021.05.001.

    • Author

    • 罗旭东,张凯月,蒋僡雯： LUO Xu-dong ZHANG Kai-yue JIANG Hui-wen LI Fang-yan CHEN Zong-yun