General Information

    • DRAMP ID

    • DRAMP29025

    • Peptide Name

    • H-21

    • Sequence

    • IKLSKⓍTKKⓍLKKVLKGⓍIKGⓍIAVAKMV

    • Sequence Length

    • 29

    • Original Sequence

    • IKLSPETKDNLKKVLKGAIKGAIAVAKMV

    • Source

    • Synthetic construct

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Comments

    • Function: Anticancer activity. Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays

    • Target Organism

      • [Ref.30789695] Cancer cell lines: A549 (IC50 = 3.26 ± 0.36 μM), HCT116 (IC50 = 3.05 ± 0.21 μM), HepG2 (IC50 = 1.50 ± 0.28 μM)

    • Hemolytic Activity

      • No hemolytic activity information found.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

Structure Information

    • Linear/Cyclic

    • Cyclic (Stapled)

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Special Amino Acid and Stapling Position

    • ① The Ⓧ (position: 6, 10, 18 and 22) in sequence indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. ② Ⓧ (6) and Ⓧ (10), Ⓧ (18) and Ⓧ (22) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple, respectively.

    • Stereochemistry

    • L

    • Secondary Structure

    • α-helical (most likely)

    • Structure Description

    • No detailed structure description found.

    • Helical Wheel Diagram

    • DRAMP29025 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP29025.

Literature Information

  • Literature 1

    • Title

    • Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy

    • Reference

    • ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.

    • Author

    • Yulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao