General Information

    • DRAMP ID

    • DRAMP35929

    • Peptide Name

    • ISHP2

    • Sequence

    • XRRKAFⓍHWYⓍG

    • Sequence Length

    • 12

    • Original Sequence

    • XRRKAFSHWYSG

    • Source

    • Synthetic construct

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Comments

    • Not available

    • Target Organism

      • Tumor cells: MCF-7 (IC50=3.71 ± 0.21 μM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

Structure Information

    • Linear/Cyclic

    • Cyclic (Stapled)

    • N-terminal Modification

    • FITC, 5(6)-carboxy fluorescence

    • C-terminal Modification

    • Free

    • Special Amino Acid and Stapling Position

    • Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling

    • Stereochemistry

    • L

    • Secondary Structure

    • No specific results about the strcture presented in the forms of tables, graphs or words

    • Structure Description

    • No other descriptive information about the structure found in the literature

    • Helical Wheel Diagram

    • DRAMP35929 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35929.

Literature Information

  • Literature 1

    • Title

    • Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors

    • Reference

    • J Med Chem. 2022 Oct 27;65(20):13866-13891.

    • Author

    • Adak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S.