General Information
-
DRAMP ID
- DRAMP35932
-
Peptide Name
- ISHP2
-
Sequence
- XRRKAFⓍHWYⓍG
-
Sequence Length
- 12
-
Original Sequence
- XRRKAFSHWYSG
-
Source
- Synthetic construct
Activity Information
-
Biological Activity
- Antimicrobial, Anticancer
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Comments
- Not available
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Target Organism
-
- Tumor cells: MCF-7 (IC50=52.33 ± 3.75 μM)
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Hemolytic Activity
-
- Not available
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Cytotoxicity
-
- Not available
Structure Information
-
Linear/Cyclic
- Cyclic (Stapled)
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N-terminal Modification
- FITC, 5(6)-carboxy fluorescence
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C-terminal Modification
- Free
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Special Amino Acid and Stapling Position
- Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
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Stereochemistry
- L
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Secondary Structure
- No specific results about the strcture presented in the forms of tables, graphs or words
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Structure Description
- No other descriptive information about the structure found in the literature
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Helical Wheel Diagram
-
Predicted Structure
- There is no predicted structure for DRAMP35932.
Literature Information
- Literature 1
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Title
- Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors
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Pubmed ID
- 36240440
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Reference
- J Med Chem. 2022 Oct 27;65(20):13866-13891.
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Author
- Adak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S.