General Information

    • DRAMP ID

    • DRAMP29350

    • Peptide Name

    • TP4-4

    • Sequence

    • FIIⓧKKSⓧGLⓧKKKⓧGAⓧKKKⓧIKK

    • Sequence Length

    • 25

    • Original Sequence

    • FIHHIIGGLFSAGKAIHRLIRRRRR

    • Source

    • Synthetic construct

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Comments

    • Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.

    • Target Organism

      • [Ref.36877022]Gram-positive bacteria: Staphylococcus aureus(MIC>25 μM; MBC>25 μM);
      • Gram-negative bacteria:Acinetobacter baumannii(MIC=12.5 μM; MBC=12.5 μM).

    • Hemolytic Activity

      • [Ref.36877022]It shows 15% hemolysis against human red blood cells at the concentration greater than 100 μM.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

Structure Information

    • Linear/Cyclic

    • Cyclic (Stapled)

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Special Amino Acid and Stapling Position

    • ①The Ⓧ (position: 4, 8, 11, 15, 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine. ②Ⓧ (4) and Ⓧ (8), Ⓧ (11) and Ⓧ (15), Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively.

    • Stereochemistry

    • L

    • Secondary Structure

    • No specific results about the strcture presented in the forms of tables, graphs or words

    • Structure Description

    • No other descriptive information about the structure found in the literature

    • Helical Wheel Diagram

    • DRAMP29350 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP29350.

Physicochemical Information

    • Formula

    • C60H90N12O13

    • Absent Amino Acids

    • CEHMNPQRTVWY

    • Common Amino Acids

    • I

    • Mass

    • 2940.88

    • PI

    • 11.18

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Hydrophobicity

    • 123.85

    • Polar Residues

    • 2

DRAMP29350

Literature Information

  • Literature 1

    • Title

    • Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. 

    • Reference

    • Microbiol Spectr. 2023 Mar 6;11(2):e0385322.

    • Author

    • Yeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY.