General Information

    • DRAMP ID

    • DRAMP29354

    • Peptide Name

    • SAU-4

    • Sequence

    • GLFⓧIIKⓧIAESF

    • Sequence Length

    • 13

    • Original Sequence

    • GLFDIIKKIAESF

    • Source

    • Synthetic construct

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Comments

    • Function: Antifungal.

    • Target Organism

      • [Ref.34439006]Fungi: C. albicans SC5314(MIC>64 μg/mL), C. albicans 901(MIC>128 μg/mL), C. albicans 904(MIC>128 μg/mL), C. tropicalis ATCC 20026 (MIC>128 μg/mL), C. tropicalis 895 (MIC>128 μg/mL), C. glabrata ATCC 1182 (MIC>128 μg/mL), C. glabrata 896 (MIC>128 μg/mL), C. auris 918 (MIC>128 μg/mL), C. auris 919 (MIC>128 μg/mL), C. krusei ATCC 2340 (MIC>128 μg/mL), C. parapsilosis ATCC 22010(MIC>128 μg/mL).

    • Hemolytic Activity

      • No hemolytic activity information found.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

Structure Information

    • Linear/Cyclic

    • Cyclic (Stapled)

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Amidation

    • Special Amino Acid and Stapling Position

    • ①The Ⓧ (position: 4 and 8) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). ②Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling respectively.

    • Stereochemistry

    • L

    • Secondary Structure

    • 73.5% α-helix in a solution of phosphate buffer and trifluoroethanol (7:3) and reached a concentration of 50 μM.

    • Structure Description

    • No other descriptive information about the structure found in the literature

    • Helical Wheel Diagram

    • DRAMP29354 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP29354.

Physicochemical Information

    • Formula

    • C30H55N11O4

    • Absent Amino Acids

    • ACDEFGHIKMNPQSTVW

    • Common Amino Acids

    • L

    • Mass

    • 1460.17

    • PI

    • 6

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Hydrophobicity

    • 34.29

    • Polar Residues

    • 0

DRAMP29354

Literature Information

  • Literature 1

    • Title

    • Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides. 

    • Reference

    • Antibiotics (Basel). 2021 Aug 9;10(8):956. 

    • Author

    • Zheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X.