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Source
- Synthetic construct
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UniProt Entry
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No entry found
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Protein Existence
- Not found
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
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- Gram-negative bacterium: Escherichia coli(LD99=3.8 µM);
- Gram-positive bacteria: Staphylococcus aureus(LD99=0.9 µM), Bacillus subtilis(LD99=0.9 µM).
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Hemolytic Activity
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- None of the peptides are hemolytic
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Cytotoxicity
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No cytotoxicity information found in the reference(s) presented
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Serum or Protease Type
- Human Serum
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Stability Data
- Resistant with ∼50% intact peptide left after an incubation time of 6.5 h.
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N-terminal Modification
- Cyclization(Cys1 and Cys8)
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C-terminal Modification
- Amidation and Cyclization(Cys1 and Cys8)
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys1 and Cys8.
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Structure Description
- Not found
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There is no predicted structure for DRAMP29851.
- ·Literature 1
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Title
- Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs.
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Reference
- PLoS One. 2010 Sep 10;5(9):e12684.
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Author
- Nguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ.