General Information

    • DRAMP ID

    • DRAMP29879

    • Peptide Name

    • cycloCP-11

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ICLKKWPWWPWRRCK

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli(MIC=16 µg/ml), Pseudomonas aeruginosa(MIC=64 µg/ml), Salmonella typhimurium(MIC=4µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus(MIC=16 µg/ml), Staphylococcus epidermidis(MIC=8 µg/ml), Enterococcus faecalis(MIC=64 µg/ml).

    • Hemolytic Activity

      • Less than 5% hemolysis of human erythrocytes was observed after 1 h of treatment with peptide at concentrations up to 256 µg/mL.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Trypsin

    • Stability Data

    • Half-life is 4 minutes.

    • Assay

    • HPLC

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys2 and Cys14.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29879.

Literature Information

  • ·Literature 1

    • Title

    • Structure-based design of an indolicidin peptide analogue with increased protease stability.

    • Reference

    • Biochemistry. 2003 Dec 9;42(48):14130-8.

    • Author

    • Rozek A, Powers JP, Friedrich CL, Hancock RE.