General Information

    • DRAMP ID

    • DRAMP29901

    • Peptide Name

    • O-23(Oncocin)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VDKPPYLPRPRPPR-Orn-IYN-Orn

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli BL21AI(MIC=8 µg/ml), Escherichia coli DSM 1103(MIC=4 µg/ml), Klebsiella pneumoniae DSM 681(MIC=2 µg/ml);
      • Gram-positive bacteria: Micrococcus luteus ATCC 10240(MIC=8 µg/ml).

    • Hemolytic Activity

      • [Ref.21185160]There was no indication of any haemolytic activity up to peptide concentrations of 600 µg/ml.

    • Cytotoxicity

      • [Ref.21185160]The MTT test against human Hela cell line did not indicate any toxicity at peptide concentrations of 600 µg/ml.

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Mouse serum

    • Stability Data

    • The half-live is 176 ±8 min in full mouse serum.

    • Assay

    • Matrix-assisted laser desorption/ionisation–time-of-flight mass spectrometry (MALDI-TOF-MS)

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Orn=Ornithine

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29901.

Literature Information

  • ·Literature 1

    • Title

    • Bactericidal oncocin derivatives with superior serum stabilities

    • Reference

    • Int J Antimicrob Agents. 2011 Feb;37(2):166-70.

    • Author

    • Knappe D, Kabankov N, Hoffmann R