General Information

    • DRAMP ID

    • DRAMP29905

    • Peptide Name

    • PEG-TRI-1144

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • TTWEAWDRAIAEYAARIEALLRALQEQQEKNEAALREL

    • Sequence Length

    • 38

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • Virus: HIV type 2

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Rat plasma, human plasma

    • Stability Data

    • The half life is 34h in rat plasma and 70h in human plasma.

    • Assay

    • LC-MS/MS

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Conjugated with PEG(40KDa) throµgh Lys-30

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29905.

Literature Information

  • ·Literature 1

    • Title

    • Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology. Eur J Pharm Biopharm

    • Reference

    • Eur J Pharm Biopharm. 2015 Jun;93:254-9.

    • Author

    • Schneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV.