General Information

    • DRAMP ID

    • DRAMP29914

    • Peptide Name

    • All-D-CATH-2(C1-15

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • rfgrflrkirrfrpk

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Human serum

    • Stability Data

    • the antibacterial activity of D-C1-15 was maintained up to 24h incubation in serum

    • Assay

    • Radial diffusion assays

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • D-Arg at 1st, 4th, 7th, 10th, 11th, and 13th position, D-Phe at 2nd, 5th, and 12th position, D-Gly at 3rd position, D-Leu at 6th position, D-Lys at 8th, and 15th position, D-Ile at 9th position, D-Pro at 14th position

    • Stereochemistry

    • D

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29914.

Literature Information

  • ·Literature 1

    • Title

    • Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization.

    • Reference

    • Peptides. 2011 May;32(5):875-80

    • Author

    • Molhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ.