General Information

    • DRAMP ID

    • DRAMP29920

    • Peptide Name

    • GnRH-III(N-Me-4Ser,8Lys(DaudAoa))

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • HWSHDWKPG

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Anti-cancer

    • Target Organism

    • No LC50s found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.21668011]IC50=10.65±2.1 μM against MCF-7 human breast cell lines, IC50>50 μM against HT-29 human colon cell lines, IC50=14.1±1.3 μM against LNCaP human prostate cancer cell lines .

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Trypsin, ?-chymotrypsin, and pepsin

    • Stability Data

    • All bioconjugates showed high stability in the presence of pepsin even after 25 h of incubation, as no proteolytic fragmentswere identified by LC-MS

    • Assay

    • LC-MS

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • K(8)=(Dau=Aoa);S(4)=-N-Me

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29920.

Literature Information

  • ·Literature 1

    • Title

    • Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4.

    • Reference

    • Bioconjug Chem. 2011 Jul 20;22(7):1320-9.

    • Author

    • Manea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G.