• DRAMP ID

    • DRAMP29942
    • Peptide Name

    • Aurein-1.2 [I6A]
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLFDIAKKIAESF
    • Sequence Length

    • 13
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • Gram-negative bacterium: Escherichia coli ATCC 25922(MIC=512µg/ml), Pseudomonas aeruginosa ATCC 9027(MIC>512 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923(MIC>512 µg/ml), Enterococcus faecalis(MIC=256 µg/ml);
      • Fungi: Candida albicans ATCC 10231(MIC=256 µg/ml).
    • Hemolytic Activity

      • All the analogs were less hemolytically active against human RBCs
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Serum or Protease Type

    • Fetal bovine serum
    • Stability Data

    • 37℃,in fetal bovine serum, 29% remaining after 6h
    • Assay

    • LC-MS
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29942.
  • ·Literature 1
    • Title

    • Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2.
    • Reference

    • Probiotics Antimicrob Proteins. 2019 Sep;11(3):1042-1054.
    • Author

    • Migoń D, Jaśkiewicz M, Neubauer D, Bauer M, Sikorska E, Kamysz E, Kamysz W.