clinical Information

    • DRAMP ID

    • DRAMP18063

    • Sequence

    • AKRHHGYKRKFH-NH(2)

    • Sequence Name

    • P113

    • Description

    • a 12 amino acid fragment of histatin 5

    • Activity

    • Antifungal

    • Medical use

    • HIV

    • Stage of Development

    • Phase II(Completed)

    • Comments

    • No more comments

    • Company

    • Demgen

    • Target Organism

      • A series of P. aeruginosa clinical isolates from CF patients(median MIC=3.1 μg/ml,the MIC at which 90% of strains were inhibited was 6.3 μg/ml)

    • Reference

      • Histatins: antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. (2004).(PMID: 15025852)
      • Structural characterization and antimicrobial activity of the Zn(II) complex with P113 (demegen), a derivative of histatin 5, Inorg. Chem. (2010).(PMID: 20815365)