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Sequence
- AKRHHGYKRKFH-NH(2)
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Description
- a 12 amino acid fragment of histatin 5
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Stage of Development
- Phase II(Completed)
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Target Organism
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- A series of P. aeruginosa clinical isolates from CF patients(median MIC=3.1 μg/ml,the MIC at which 90% of strains were inhibited was 6.3 μg/ml)
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Reference
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- Histatins: antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. (2004).(PMID: 15025852)
- Structural characterization and antimicrobial activity of the Zn(II) complex with P113 (demegen), a derivative of histatin 5, Inorg. Chem. (2010).(PMID: 20815365)