• DRAMP ID

    • DRAMP18064
    • Sequence

    • AKRHHGYKRKFH(in the D configuration)
    • Sequence Name

    • P113D
    • Description

    • a 12 amino acid fragment of histatin 5
    • Activity

    • Antifungal
    • Medical use

    • an inhalation treatment for Pseudomonas aeruginosainfections in cystic fibrosis patients
    • Stage of Development

    • Unknow
    • Comments

    • No more comments
    • Company

    • Demgen
    • Target Organism

      • nonmucoid P. aeruginosa strain ATCC 27853(LD90=1.25 μg/ml ).P-113D was also as active as P-113 against the battery ofP. aeruginosa clinical isolates.
    • Reference

      • Histatins: antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. (2004).(PMID: 15025852)
      • P-113D, an Antimicrobial Peptide Active againstPseudomonas aeruginosa, Retains Activity in the Presence of Sputum from Cystic Fibrosis Patients.Antimicrob. Agents Chemother.(2001)(PMID: 11709321)