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Description
- an 11-mer peptide from the N terminus of human lactoferrin
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Activity
- Antibacterial, Antifungal
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Medical use
- LPS-mediated diseasesand fungal infections
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Stage of Development
- Phase I(Completed)
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- hLF1-11 has proved efficacious in animal models of osteomyelitis and other bacterial infections.Significant efficacy observed in Phase I trials; mechanism of action appears to be immunomodulatory rather than antibiotic.
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Company
- AM-Pharma Holding BV
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Target Organism
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- In vivo,a dose-dependent bacteriocidal effect of intravenous administered peptide was observed in both immunocompetent and -compromised mice with a MRSA infection and hLF1-11 0.4–40µg/kg reduced 2 – 3 logs of bacterial counts in mice
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Reference
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- Comparable efficacies of the antimicrobial peptide human lactoferrin 1–11 and gentamicin in a chronic methicillin-resistantStaphylococcus aureusosteomyelitis model. Antimicrob. Agents Chemother.(2005).(PMID: 15917544)
- Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria. Infect. Immun.(2001)(PMID: 11179314)
- The high effective antimicrobial peptide hLF (1-11) may be given to (immunocompromised) mice with a multidrug resistant Staphylococcus aureusinfection by various routes. 45th Interscience Conference on Antimicrob. Agents Chemother.Washington DC, USA (2005)