• DRAMP ID

    • DRAMP18074
    • Sequence

    • Structure not disclosed
    • Sequence Name

    • CSA-13
    • Description

    • cationic steroid (ceragenin) that mimics host-defense peptides
    • Activity

    • Unknow
    • Medical use

    • Anti-infective
    • Stage of Development

    • Preclinical
    • Comments

    • No more comments
    • Company

    • Ceragenix(Denver)
    • Target Organism

      • In planktonic cultures, the minimal inhibitory and minimal bactericidal concentrations of CSA-13 were in the 1-25 mg/L range except for one mucoid clinical strain which was much less sensitive to tobramycin (minimal bactericidal concentration, 65-125 mg/L). At concentrations higher than 20 mg/L, it permeabilized the plasma membrane of human umbilical vein endothelial cells.
    • Reference

      • Interaction between tobramycin and CSA-13 on clinical isolates of Pseudomonas aeruginosa in a model of young and mature biofilms.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.2010 Sep.(PMID: 20625718)