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Description
- cationic steroid (ceragenin) that mimics host-defense peptides
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Target Organism
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- In planktonic cultures, the minimal inhibitory and minimal bactericidal concentrations of CSA-13 were in the 1-25 mg/L range except for one mucoid clinical strain which was much less sensitive to tobramycin (minimal bactericidal concentration, 65-125 mg/L). At concentrations higher than 20 mg/L, it permeabilized the plasma membrane of human umbilical vein endothelial cells.
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Reference
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- Interaction between tobramycin and CSA-13 on clinical isolates of Pseudomonas aeruginosa in a model of young and mature biofilms.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.2010 Sep.(PMID: 20625718)
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Medical use
- Anti-infective
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Company
- Ceragenix(Denver)
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Stage of Development
- Preclinical
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