Sequence Information

    • DRAMP ID

    • DRAMP18156

    • Name

    • RDP58(Delmitide)

    • Sequence

    • rxxxrxxxgy

    • Description

    • Semisynthetic D-amino acid decapeptide derived from HLA class I B2702

    • Activity

    • Unknown

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Potential of immunomodulatory host defense peptides as novel anti-infectives.Trends in Biotechnology(2009).(PMID: 19683819)
      • RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.Inflamm. Bowel Dis.(2005)(PMID: 16043985)

Clinical Information

    • Medical use

    • Inflammatory bowel disease

    • Company

    • Genzyme; licensed to Procter&Gamble

    • Stage of Development

    • Post Phase II

    • Comments

    • A protease-resistant, d-amino acid-containing peptide with similar efficacy to asacol; attempting to improve activity through formulation.

    • Clinical Trials

    • 2004-004077-29(EudraCT)