Sequence Information

    • DRAMP ID

    • DRAMP29315

    • Name

    • Bacitracin

    • Sequence

    • Unk-Leu-D-Glu-Ile-Lys-D-Orn-Ile-D-Phe-His-D-Asp-Asn

    • Description

    • Bacitracin A is a homodetic cyclic peptide consisting of (4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid attached head-to-tail to L-leucyl,D-glutamyl, L-lysyl, D-ornityl, L-isoleucyl, D-phenylalanyl, L-histidyl. D-aspartyl and L-asparaginyl residues coupled in sequence and cyclised by condensation of the side-chain amino group of the L-lysyl residue with the C-terminal carboxylic acid group. It is the major component of bacitracin. It has a role as an antibacterial agent and an antimicrobial agent. It is a homodetic cyclic peptide and a polypeptide.

    • Activity

    • Antibacterial

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Peptide and protein drugs: the study of their metabolism and catabolism by mass spectrometry.(PMID: 21698655)

Clinical Information

    • Medical use

    • prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.

    • Company

    • Stage of Development

    • In market

    • Comments

    • Bacitracin binds to a divalent metal ion such as Mn(II), Co(II), Ni(II), Cu(II), or Zn(II).1 These complexes bind C55-isoprenyl pyrophosphate, preventing the hydrolysis of a lipid dolichol pyrophosphate, which finally inhibits cell wall synthesis.1 Bacitracin metal complexes also bind and oxidatively cleave DNA.