Sequence Information

    • DRAMP ID

    • DRAMP29333

    • Name

    • Gramicidin D

    • Sequence

    • VGALAVVVWLWLWLW-ethanolamine

    • Description

    • Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. Active against most Gram-positive bacteria and some Gram-negative organisms, Gramicidin D is used primarily as a topical antibiotic and is also found in Polysporin ophthalmic solution.

    • Activity

    • Antibacterial

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Identification of Effective Dimeric Gramicidin-D Peptide as Antimicrobial Therapeutics over Drug Resistance: In-Silico Approach.(PMID: 30182355)

Clinical Information

    • Medical use

    • Skin lesions, surface wounds and eye infections

    • Company

    • Unknown

    • Stage of Development

    • In market

    • Comments

    • No more comments