• DRAMP ID

    • DRAMP04728
    • Sequence

    • KNLRRSIRKIIHIIKKYG
    • Sequence Length

    • 18
    • Sequence Name

    • Sequence 5 from Patent US 20020082195
    • Source

    • Synthetic construct
    • Activity

    • Antibacterial
    • Patent Type

    • Patent Application
    • Publication Date

    • 2002-6-27
    • Patent Title

    • Novispirins: antimicrobial peptides.
    • Abstract

    • Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.