Patent Information

    • DRAMP ID

    • DRAMP05073

    • Sequence

    • ILPWKWPWWPWWPWRR

    • Sequence Length

    • 16

    • Sequence Name

    • Sequence 11 from Patent US 20040019181

    • Source

    • Synthetic construct

    • Activity

    • Antimicrobial

    • Patent Type

    • Patent Application

    • Publication Date

    • 2004-1-29

    • Patent Title

    • Antimicrobial cationic peptides.

    • Abstract

    • A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas: X 1 X 1 PX 2 X 3 X 2 P(X 2 X 2 P) n X 2 X 3 (X 5) 0; (SEQ ID NO: 23) X 1 X 1 PX 2 X 3 X 4 (X 5) r PX 2 X 3 X 3; (SEQ ID NO: 24) X 1 X 1 X 3 (PW) u X 3 X 2 X 5 X 2 X 2 X 5 X 2 (X 5) 0; and (SEQ ID NO: 25) X 1 X 1 X 3 X 3 X 2 P(X 2 X 2 P) n X 2 (X 5) m; (SEQ ID NO: 26) wherein: m is 1 to 5; n is 1 or 2; o is 2 to 5; r is 0 to 8; u is 0 or 1; X 1 is Isoleucine, Leucine, Valine, Phenylalanine, Tyrosine, Tryptophan or Methionine; X 2 represents Tryptophan or Phenylalanine X 3 represents Arginine or Lysine; X 4 represents Tryptophan or Lysine; and X 5 represents Phenylalanine, Tryptophan, Arginine, Lysine, or Proline. The invention also provides a method of producing a cationic peptide variant having antimicrobial activity.