Patent Information

    • DRAMP ID

    • DRAMP36494

    • Sequence

    • TCRSSGRYCRSPYDRRRRYCRRITDACV

    • Sequence Length

    • 28

    • Sequence Name

    • GexIVA[1,2]

    • Source

    • Alpha O-conotoxin

    • Activity

    • Antimicrobial, Anticancer

    • Patent Type

    • Granted Patent

    • Publication Date

    • 2020-12-1

    • Patent Title

    • Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof

    • Abstract

    • The invention belongs to the fields of biochemistry, molecular biology and neuroscience, and relates to a novel alpha O-conotoxin GeXIVA mutant, a pharmaceutical composition and application thereof. Specifically, the invention relates to an isolated polypeptide, the amino acid sequence of which is that one or more amino acids in a mother sequence are removed, or one or more amino acids in the mother sequence are replaced by L-type amino acids or D-type amino acids with the same number, wherein the mother sequence is SEQ ID NO. 1, SEQ ID NO. 62 or SEQ ID NO. 63; and the polypeptide has activity of blocking alpha 9 alpha 10 nAChR. The polypeptide can specifically block alpha 9 alpha 10nAChR, and has good application prospect in the aspects of preparing analgesic drugs, drugs for treating mental diseases and cancers, neuroscience tool drugs and the like.