General Information

    • DRAMP ID

    • Peptide Name

    • Hymenochirin-1B

    • Source

    • Hymenochirus boettgeri (Congo dwarf clawed frog)

    • Family

    • Unknown

    • Gene

    • Sequence

    • IKLSPETKDNLKKVLKGAIKGAIAVAKMV

    • Sequence Length

    • 29

    • Protein Existence

    • Experimental evidence at transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.24172540] Gram-positive bacteria:
        Target OrganismActivity
        S. aureus ATCC 29213MIC = 12.5 μM
        S. aureus ATCC 25923MIC = 12.5 μM
        S.epidermidis RP62AMIC = 3.1 μM
        S.epidermidis RP62A/1MIC = 1.6 μM
        C.albicans ATCC 90028 (MIC = 100 μM);-
      • Gram-negative bacteria:
        Target OrganismActivity
        E.coliMIC = 25 μM
        A. baumanniiMIC = 6.25 μM
        S. maltophiliaMIC = 6.25 μM
        K. pneumoniaeMIC = 25 μM
        P. aeruginosaMIC = 50 μM
        P.mirabilisMIC > 100 μM

    • Hemolytic Activity

      • [Ref.24172540] LC₅₀ = 213 ± 18 μM against freshly prepared human erythrocytes.

    • Cytotoxicity

    • Binding Target

Structure Information

    • Linear/Cyclic

    • N-terminal Modification

    • C-terminal Modification

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • Structure

    • α-helical (most likely)

    • Structure Description

    • No structure indentification experiment and detailed structure description found

    • Helical Wheel Diagram

    • helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for .

Physicochemical Information

    • Formula

    • Absent Amino Acids

    • Common Amino Acids

    • Mass

    • 0

    • PI

    • 0

    • Basic Residues

    • Acidic Residues

    • Hydrophobic Residues

    • Net Charge

    • Boman Index

    • 0

    • Hydrophobicity

    • 0

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:

    • Extinction Coefficient Cystines

    • Absorbance 280nm

    • 0

    • Polar Residues

chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Pubmed ID

    • Reference

    • Author