Sequence Information

    • DRAMP ID

    • DRAMP18063

    • Name

    • P113

    • Sequence

    • AKRHHGYKRKFH

    • Description

    • a 12 amino acid fragment of histatin 5

    • Activity

    • Antifungal

    • Target Organism

      • A series of P. aeruginosa clinical isolates from CF patients(median MIC=3.1 μg/ml,the MIC at which 90% of strains were inhibited was 6.3 μg/ml)

    • Reference

      • Histatins: antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. (2004).(PMID: 15025852)
      • Structural characterization and antimicrobial activity of the Zn(II) complex with P113 (demegen), a derivative of histatin 5, Inorg. Chem. (2010).(PMID: 20815365)
      • Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study. (2002).(PMID: 11895545)

Clinical Information

    • Medical use

    • Reduce gum bleeding, gingivitis and plaque

    • Company

    • Demgen

    • Stage of Development

    • Phase II

    • Comments

    • No more comments

    • Clinical Trials

    • NCT00659971