Sequence Information

    • DRAMP ID

    • DRAMP18081

    • Name

    • PAC113

    • Sequence

    • AKRHHGYKRKFH

    • Description

    • based on the active segment of histatin 5 protein found in human saliva

    • Activity

    • Antifungal

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Not available

Clinical Information

    • Medical use

    • Oral candidiasis in HIV seropositive patients

    • Company

    • Pacgen(Vancouver, BC, Canada)

    • Stage of Development

    • Phase IIb

    • Comments

    • Current treatments for Candida infections are either only marginally efficacious, have poor patient compliance characteristics, can cause serious side effects, can lead to drug-resistance and/or have multiple drug interaction issues.Phase IIb results: 34% increase in primary end point efficacy level; Phase III trial not initiated

    • Clinical Trials

    • NCT00659971