Sequence Information

    • DRAMP ID

    • DRAMP18083

    • Name

    • CZEN-002(Melantropin, (CKPV)2)

    • Sequence

    • SYSMEHFRWGKPV

    • Description

    • CZEN-002 is a novel, non-azole anti-fungal synthetic octapeptide, derived from alpha-Melanocyte-Stimulating Hormone (a-MSH). CZEN-002 modulates inflammatory and immune responses. It has also been shown to kill Candida albicans (C. albicans), a single-celled fungal organism that causes a variety of infections, including vaginitis. This organism can invade tissues and produce fatal infections in individuals with compromised immune systems such as those suffering from HIV/AIDS or undergoing organ or bone transplants. The antimicrobial activity of CZEN-002 is unique in that it does not depend on direct damage to the microbial membrane. It appears that CZEN-002 works on a receptor in yeast that has yet to be identified.

    • Activity

    • anti-candidal

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Antimicrobial peptides: therapeutic potential. Expert Opin. Pharmacother. (2006).

Clinical Information

    • Medical use

    • GPB, GNP, Candida. Yeast regulatory mechanisms, Interference by cAMP induction, anti-inflammatory.

    • Company

    • Zengen(Woodland Hills, CA, USA)

    • Stage of Development

    • Phase IIb

    • Comments

    • Positive efficacy results announced. Phase IIb trial is a dose-ranging study

    • Clinical Trials

    • 2005-001360-31