Sequence Information

    • DRAMP ID

    • DRAMP18158

    • Name

    • PMX-30063(brilacidin)

    • Sequence

    • Not available

    • Description

    • Defensin structural mimetic, non-peptide,small molecule/copolymer

    • Activity

    • Antibacterial

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Potential of immunomodulatory host defense peptides as novel anti-infectives.Trends in Biotechnology(2009)(PMID: 19683819)
      • An approach to new antibiotics for avoiding resistance: PMX-30063.INFLAMMATION RESEARCH(2010).

Clinical Information

    • Medical use

    • Acute bacterial skin infections caused by Staphylococcusspp

    • Company

    • PolyMedix

    • Stage of Development

    • Phase II

    • Comments

    • In the phase I study, PMX30063 at an intravenous dose of 0.54mg/kg(as well as at higher doses)caused sensory nerve symptoms man-ifesting as paresthesias(Polymedix press release,Decem-ber10,2008).

    • Clinical Trials

    • NCT01211470
    • NCT02052388