Sequence Information

    • DRAMP ID

    • DRAMP18165

    • Name

    • CD-NP(Cenderitide)

    • Sequence

    • GLSKGCFGLKLDRIGSMSGLGCPSLRDPRPDAPSTSA

    • Description

    • Synthetic chimeric 37-mer derived from combination of two natriuretic peptides

    • Activity

    • Unknown

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • A PHASE II, DOSE-RANGING STUDY WITH CD-NP, A CHIMERIC NATRIURETIC PEPTIDE, IN ACUTE DECOMPENSATED HEART FAILURE PATIENTS WITH RENAL COMPROMISE

Clinical Information

    • Medical use

    • Acute decompensated failure (ADHF),Organ failure

    • Company

    • Nile Therapeutics (United States, Minnesota).

    • Stage of Development

    • Phase II

    • Comments

    • CD-NP at 1.25 and 2.5 ng/kg/min appeared to preserve renal function relative to placebo as measured by renal biomarkers

    • Clinical Trials

    • NCT02071602
    • NCT02359227
    • NCT02603614
    • NCT00839007
    • NCT00699712