Sequence Information

    • DRAMP ID

    • DRAMP18180

    • Name

    • Buforin II

    • Sequence

    • TRSSRAGLQWPVGRVHRLLRK

    • Description

    • Asian Toad (Bufo bufo gargarizans) stomach

    • Activity

    • Antibacterial(nucleic acids)

    • Target Organism

      • 90% inhibition of S.aureus(MIC= 8μM)

    • Reference

      • Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem Biophys Res Commun (1998).(PMID: 9514864)
      • Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria. Peptides (2000).(PMID: 11035200)

Clinical Information

    • Medical use

    • Staphylococus aureusanti-infectives

    • Company

    • Unknown

    • Stage of Development

    • Preclinical

    • Comments

    • No more comments

    • Clinical Trials