General Information

    • DRAMP ID

    • DRAMP37343

    • Peptide Name

    • RIKL(Designed by molecular dynamics simulation)

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RIKLRIKLLRLLRL

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 29213(MIC=4μmol/L), Staphylococcus aureus ATCC 25923(MIC=8μmol/L), Staphylococcus epidermidis ATCC 12228(MIC=4μmol/L), Bacillus subtilis CMCC 63501(MIC=8μmol/L)
      • Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=2μmol/L), Escherichia coli UB1005(MIC=2μmol/L),Escherichia coli K88(MIC=2μmol/L), Salmonella typhimurium ATCC 14028(MIC=2μmol/L),Salmonella pullorum C79–13(MIC=2μmol/L)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix structure in simulated hydrophobic environment

    • Structure Description

    • RIKL presents an irregular curly structure in PBS. In 50%TFE solution, the spectral signature of RIKL shows two negative peaks near both about 207 nm and 226 nm, which proves that RIKL forms an α-helix structure in a simulated hydrophobic environment

    • Predicted Structure

    • There is no predicted structure for DRAMP37343.

Literature Information

  • ·Literature 1

    • Title

    • 抗菌肽RIKL的分子设计及生物学活性分析：Molecular design and biological activity analysis of antimicrobial peptide RIKL

    • doi

    • 10.13345/j.cjb.210219.

    • Reference

    • [J].生物工程学报,2022,38(01):174-184.DOI:10.13345/j.cjb.210219.

    • Author

    • 方禹鑫,李玲,付文华： FANG Yuxin LI Ling FU Wenhua DONG Na SHAN Anshan