General Information

    • DRAMP ID

    • DRAMP00218

    • Peptide Name

    • Plantazolicin (PZN; Bacteriocin)

    • Source

    • Bacillus amyloliquefaciens FZB42 & Bacillus pumilus (Bacillus mesentericus) (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • pznA

    • Sequence

    • RCTCTTIISSSSTF

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus subtilis HB0042, Bacillus subtilis strain 168, Bacillus megaterium 7A1, Bacillus anthracis (MIC=2-4 µg/ml), Bacillus brevis strain ATCC 8246, Bacillus cereus strain ATCC 14579 and strain CU1065, Bacillus licheniformis strain ATCC 9789, Micrococcus luteus, Bacillus sphaericus, Paenibacillus granivorans and Streptococcus pyogenes (MIC=128 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic (possibly)

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • 10 residues (Cys, Ser/Thr) potentially serve as a site of heterocycle formation

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00218 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00218.

Physicochemical Information

    • Formula

    • C61H103N17O23S2

    • Absent Amino Acids

    • ADEGHKLMNPQVWY

    • Common Amino Acids

    • ST

    • Mass

    • 1506.71

    • PI

    • 8.07

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +1

    • Boman Index

    • -23.42

    • Hydrophobicity

    • 0.45

    • Aliphatic Index

    • 55.71

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 9.62

    • Polar Residues

    • 10

DRAMP00218

Comments Information

    • Function

    • Peptide antibiotic inhibiting growth of Gram-positive bacteria

Literature Information

  • ·Literature 1

    • Title

    • Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42.

    • Reference

    • J Bacteriol. 2011 Jan;193(1):215-224.

    • Author

    • Scholz R, Molohon KJ, Nachtigall J, Vater J, Markley AL, S¼ssmuth RD, Mitchell DA, Borriss R.